Depends on your tone goals.
For an old school fat tone, mine sounded great with 15" cabs. I liked it better with 2 - 15" cabs then a single 15" + 210 cab, but that was because the older Mesa Diesel 2x10 cab couldn't keep up with the Eminence 3015 loaded 1x15".
I'm currently using a fEarful 15/6 cab which sounds great, the strong upper mid freq response of this cab brings more versatility to the minimalist DB750 tone controls.. but it still sounds the best with gain up past 2 and all tone knobs around 12 o'clock.
