I have a little bit of an oddball setup:
1967 Ampeg BT-15 into a Mosvalve power amp, going "stereo" out into each side of my 2x15, with each speaker getting 80 watts.
Details on the wiring here: Peavey 2x15 Project - Complete
The cab can run either two separate 4 ohms inputs, or a single 8 ohms. Now on to the question
I really, really like my current setup. I can push the BT-15 (which is really just being used as a pre) nice and hard, and then use the power amp to control the volume without changing the tone.
The problem: This thing is not light.
The PF350 power output at 8 ohms is better (250 vs the 160 I have now) and it is substantially lighter.
I have yet to get to Guitar Center yet to try, but can you get a nice "growl" or distorted sound out of the PF350 without obscene volume levels?