Dude in one of my bands plays/gigs acoustic guitar, mandolin, banjo, accordion and keys though his B100R. He gets plenty of stage volume and they all sound pretty good. I've also heard him play some clean-ish rhythm with a les paul using his tech-21 comptortion pedal/B100R, (that sounded good) I'd imagine It'd sound alright using overdrive pedals, but I've never heard him do that.
I turned him on to rehearsing/gigging through my B100R like 7 years ago and he quickly bought one of his own. He still uses it for louder gigs, but nowadays he's REALLY
digging using my old 66 fliptop for rehearsals here at my home studio: