| You can use an adapter to make the physical connections just fine, but the output signal of the REDDI vs. the input sensitivity (?) on the amp would be the concern. Most amps want an instrument level signal. The REDDI puts out a much stronger signal (mic or line level...I forget). Even with the Level Control on the REDDI turned way down it's a hot signal. I've had some trouble clipping the preamps of some lesser interfaces and mixers. It really seems to like to be plugged into high end gear.
Someone else can much better explain the technical details than me, but that's my basic understanding.
I'm not really sure what you'd benefit from doing that though. You've got no tone shaping, so it would just be adding the coloration of the REDDI into the amp. If you want a tube tone in an amp a Mesa Walkabout, GB Streamliner, or full on tube amp would probably be a better/lighter/smaller option. If you don't already own a REDDI, getting one of those wouldn't cost that much more either.
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