Zero issue, and yes, it is a very good combo IMO. Nice 'yin and yang' between the smooth, fat, open, relaxed tone of the HD112 and the tight and bright tone of the Shuttle.
That will be a killer little rig that will be able to handle larger, louder gigs that you would think. And, you can always add a second HD112. Two with that amp would literally handle any gig you could possibly do.