I've only used them in rehearsals and lower volume jazz gigs.
The 212MBE's have also been used as PA subs. They are the 4 ohm version and I fed them 600w each - it was a hard rock band but a fairly small room, just kick and no bass in them. On bass I've only run one at a time (as they are 4 ohm) and they sound OK. I probably should open them up and put batting in them but if you like your cabs a bit on the aggressive side as-is is fine. I have the tweeter switched off.
One of the 2x10's with either amp will keep up with a moderate drummer but just barely. I've not run both 2x10's together yet. Obviously one of the 4 ohm ported 2x12's is quite a bit louder, well into earplugs needed territory as I'm sure the pair of 2x10's would be