| #1 with in reason no. though I have head stories of some 60's band, Cream? that would run the speaker out of one amp to the input of another. It would sound brilliant for about 30 minutes than blow up. So as long as you arent exceeding a volt or so I am sure you are fine. People have been using clean boost pedals on amps for decades.
#2 I am not 100% on this but from what I understand, even with preamp tubes it shortens the life somewhat to play on them while they warm up. Though I don't think it takes more than 30 sec for them to get warmed up enough.
Some guys I know like to leave there amps plugged in for an hour or two before the show so that they are fully ready to go.
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