If I didn't "backyard build" my own speakers, I'd most likely be playing a NeoX. They just work.
I can see the appeal of a 412. A lot of people say "midular...more trips with ligher/smaller stuff". I can appreciate making less trips, especially over distance. Then the more trips becomes more of a hassle than the bigger stuff.
Thankfully, a pair of good 12's does what I need done, so it's a non-issue, and would rather move a single 212 rather than a pair of 112's. There is some outdoor stuff once in a while I could use a 3rd 12., but for now, I just crank hell out of the 2 of them.
For those who don't build, I think a 4ohm 212 + an 8ohm 112 with either a 2 ohm stable, or 2 channel amp, could do just about anything.
Both of those are offered in the NeoX line, BTW.