Getting a pre-packaged set in non-standard gauges like that could be a tricky proposition. Most bricks 'n' mortar stores are not going to have much selection available. Try JustStrings.com, and see what makes/models they have available on a single string basis, so you can choose the exact gauge you want for each string.
Regarding set-up, you'll most likely need to swap in a new nut, with string slots cut to fit the new, lighter-gauge strings. A truss rod adjustment and a tweaking of the action and the intonation will probably be in order as well.
A Peavey Cirrus tuned EADGC is going to sound super crisp, sharp and clear. You should be able to play some excellent chordal material on it. A few months ago, I played a Cirrus 5 (in standard tuning) for the first time, and was absolutely blown away by the crystalline clarity of it...
MM