I've been wanting to step up my string gauge, I play the standard .45-.105 but I was hesitant because I figured that I would have to replace or modify the nut in order to house them?
.110's should be ok. If you go farther, like to tune BEAD, then you might need to file the nut some. With the heavy set you're taking about, your bass could be tuned down to D standard, DGCF.