| Yes.
Even if you didn't use an alternate tuning, you would need to readjust intonation, maybe string height, and neck relief if you changed to different strings. Maybe even just a new set of the same old strings.
And almost certainly you have to check and adjust neck relief when seasons change and maybe even more often if your neck is susceptible to moving around on you.
However, the good news is that these things are realtively easy to do. Search around and you'll find great information on how to do these things.
It's just turning screws. Read carefully, go slowly, and you should be OK.
Biggest warning would be on the neck. Make sure you know where it is and where you want it to be, and make changes only veeery slowly. Like 1/8 to 1/4 turn per day at the most.
To give you and idea.... I bought a new Jaguar bass a couple weeks ago. It was warm and we hadn't yet turned the AC on for the Summer. I had it set up and it played like a dream.
Last night, I went to play it (after the AC has been on for a week) and it sounded like crap! Buzzing and strings rattling all over. So tonight I'm going to loosen up that truss rod oh just about an eighth of a turn and it'll probably be good to go as long as it is in the house.
Now, if I play outdoor gigs with it in the Summer, I need to keep my eye on it and get a feel for it - see how it reacts. Once I get to know my bass, I'll be able to make such adjustments almost on the fly.
Make sense?
Cheers!
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Basses: Geddy Lee, Jaguar, Fender PB-551, Mark Hoppus Jazz, Michael Kelly Firefly
Head: Markbass LittleMark II
Cab: Markbass Traveler 102P x 2
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