| What you want is a really strong, firm grip between the neck and body. This will allow for more vibrations (and thus deep tone) to come through. My Schecter C-5 has a 6 screw neck, but then again the classic Fenders have 5.
My advice is to fit the neck ultra snug and tight. Every screw should be very tight with great coupling.
Assuming you have a 'standard' size neck plate, I would do the normal 4, with a central screw for extra bite. This should allow for better coupling and security.
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Bring the noise!
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