| There are two pirmary reasons for a one-peice saddle on acoustic instruments. First, the way the body vibrates with the strings makes the intonation a bit more forgiving. I recall reading that Leo Fender's first guitar experiments did not have adjustable intonation and the pre-purchased necks he used didn't play in tune well. They worked fine on acoustic bodies, but when he put them on his solid bodies, the intonation issues were very noticalbe.
The biggest reason is that the expense of making an adjustable bridge for acoustics (the cost is that it totally destroys the transfer of string vibrations to the top of the instrument) isn't worth the improvement you get.
Can you get it set up well enough to work? Depends on the strings, the neck, and your standards of "well enough". Fender regular 150 guitar strings are (or at least used to be, I hate 'em so I haven't checked the gauges in decades) had goofy gauges compared to everyone else in the world. That's because if you used a set of 150's on stock Telecaster 3-piece bridge, you could get each pair of strings to intonate pretty well.
So, if the strings and the action you choose happens to line up well with the particular instrument, a one-peice bridge could intonate well. But on a solid-body electric bass, it's pretty easy and generally sonically acceptable to provide individual adjustments, so most makers do that.
jte
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JTE Spelling, grammar, and punctuation do matter, despite the threats of death by grease fire!
"Without space, music is just noise piling up on itself." TRK
Lakland Owners' Club # 248
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