| Sure...but it helps somewhat when you route them like how I do: through either a GCX or through a pedalboards.com (or other) true bypass effects switcher. I have something at the end of my chain that helps me with signal loss a little bit, and in fact my tech will be installing some buffer devices soon to help me tighten it all up. Tubescreamer's do not have much bottom, so you will lose out on that. Look for TS clones that have bass & treble control.
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Jerose: "Don't forget LEDs!...you need enough to effectively render an assailant blind...once he's defeated you can reward yourself with Pez".
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