Ackward because of balance? If so, make sure the bass is leaning back onto you, you may need to re-examine how you balance the instrument. You should hardly need to hold it up, and therefor those notes should be quite easy to play.
Ackward because you're clocking the C bout of your bass or leg? Your bass may have a low neck projection angle (or whatever that term should be), and it just may be a hard bass to play on the E string on. If you're hitting your leg however, it's again a matter of how you are standing/balancing.