I started out like you, Zooberwerx, with mixer, signal processing and amplification in the same rack. It turned out to be too much for this old fart with a torn rotator cuff, and no roadies, to handle.
Dropping something was always a risk, loading-in/out always required help, speaker cables were longer, bulkier, and heavier, etc..
I now have [new, lightweight] amps is one rack, signal processing in another, my mixer in its own case, and keep well-labeled snakes in a wheeled box of their own to hasten interconnection. Although help is always welcome, no single box is now too heavy or bulky for me to handle by myself.
I like being able to place the amps close to cabs and use shorter speaker cables, while keeping signal processing gear near the mixer.
As usual, IME - IMO - YMMV - MIC - KEY - MOUSE
