when I first started my hands would get raw. but after a while I developed a good enough callous that it hasnt gone away, even though I pretty much stopped thumbing for a few years. but yeah, what the other guy said about going thru, I find it helps to practice across the fretboard. All the strings. You wont even get a sound out of some of the strings sometimes, but keep at it! 
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Stingray club #90, Sterling club #90, EBMM club #102. Ovation Magnum club #1, Mesa Bass 400,400+ Club #14, Big Cabs Club #179, Mesa Boogie club #1317
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