There was some discussion about this toward the end of
this thread.
I'm going to reiterate my belief that that a small box with; a M9 style interface to choose amp models and settings, a separate cab model knob (multi-position switch with no cab option), a XLR balanced out (with ground lift and separate volume out, or DB pad), a bypass switch, and a beer cozy would be the coolest DI box ever.
So long as it sounded good and was sturdy enough for proper abuse.
(Beer cozy optional)