| How do you mean the low B is too low? You don't like the sound of it, or the amp doesn't reproduce it well enough? That cab should push the low B out pretty well - I used a SVT 4x10 for a while and it sounded great.
As far as the different tuning affecting your setup - it will throw off your intonation and string height, and the neck may react to the different string tension, so yes you'll need a new setup.
I've been playing a 5 tuned EADGC for about six months now and I love it, but the tuning may not really suit your style. I'm really into high, dense chords and melodic playing and it works perfectly for me.
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