If it is a major chord use the 3.
If it is a minor chord use the b3.
This may come in handy.
http://www.smithfowler.org/music/Chord_Formulas.htm The major chords will all have a 3 and the minor chords will all have a b3.
Most blues is major and you will see a lot of dominant sevenths used, A7, D7, E7 etc so you may want to throw in some b7's into the mix ......... R-3-5-b7.
There is always the blues scale. Run the blues scale with the chord changes or just run the tonic blues scale over the entire progression.
Blues scale is R-b3-4-b5-5-b7. The governing factor is how much of the cord tone or scale can you use before the music moves on. Running the scale in scale order, over and over sounds like you are running the scale, over and over ---- have some pauses in there. Groove it.
See what you can do with this.
http://www.youtube.com/watch?v=bUK5pE5x_6A
Start with just roots and groove them to the music. Then add the five in R-5-R-5 and when you can keep up add the 3's and the b7. See what sounds best to you.
Look what is waiting for you on the right hand side of the screen.
Have fun.