From a basic blues approach it is just using the 3rd of the chord (Maj and Dom 7) as it passes through the change. Certain Blues songs will have the 5-6-4 option over the bars 9 and 10 ( 12 bar format ) before a turnaround as rather than a 5-4-1. Of course in G maj the 6th is the reletive minor root note of E Minor.
If you play Hey Joe by Hendrix, it can be used as a useful
tension to play the C# in place of the A.
So it would be C-G-D-C#-E as opposed to C-G-D-A-E.
Use it sparingly is the secret....plus knowing when to and of course when not to
