All kinds of differences in picks.
Size, shape, thickness, hardness, "give," grip, material, feel, the way they wear...
I prefer nylon picks- specifically Herco .75mm.
My other favorites are the Brain 1mm and 1.14mm (I really love the grip on these, I was introduced to them as "cat's tongue picks." The grip feels like a cat's tongue!
And the Jim Dunlop 1mm and .88mm nylon.
