Use the same gauge cable. Also, I don't think you really need 10-gauge cables, 12 should work just fine. Besides, Speakon connectors won't accept 10-gauge wire, so they have to be "thinned out" to go into the recepticle. If you splice different gauge cables, you might as well just use one of the thinner gauge. I'm using 40-foot 12-gauge cables running to my 1,400-watt (program) subs with no problems.
For smaller venues, I have 25-foot, 12-gauge cables for my mains and, since the amps are usually on one side of the stage, one of the cables may be a little too short. So I have another 10-foot, 12-gauge cable that I connect to one to make it longer. I use a speakon-to-speakon adapter that's available from Parts Express. Don't worry about different cable lengths. The difference impedance is negligible from, say, 25 to 50 feet.
Speakon to Speakon connector 