| 1. Have you tried plugging a headphone into the ME-50B? That way you can hear whether the effect is adding the hiss, or whether you should also look into the cables / amp.
2. What settings (effects + position of each knob) are you using when you get that hiss? As mentioned in the manual, some effects will lead to increased noise, in particular when you set the gain rather high.
If you can specify all these settings, I could have a look whether I experience a noticeable hiss as well.
3. Have you adjusted the noise reduction knob, and how much does this help?
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In the words of 'Bunkur': why use downtuned guitars if you can have 2 basses? ;)
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