Of course it all depends on the genre of music, but here is how I use mine for church/ modern rock sounds:
If you watch the demo video that Will Davies did, I start with the "Tube Grit" setup from the video. I like the brightness of having the blend knob at 100% with the drive at 10:00. I play a MM Sterling 5HH finger style, so I flip the attack switch up and the Grunt switch to the bottom setting. This gives me a nice midrange growly yet warm tone. If I dig in a little, I can add more grit. I keep my bass EQ flat and my Mesa M6 EQ is mostly flat as well. I LOVE the attack of this pedal live. All of my runs and rhythm tracking with the drummer is heard clearly. I let this pedal do most of the heavy lifting for my system EQ.
ZWKoch, S.A.S.S. #124; Fuzzrocious #150; Club Verellen #20; Five String Bass Club #558, Wisconsin Bassist #137; Club Microtubes #7; fEARful #91.