My usual settings are treb max, mids max, bass half, gain max (last couple of runs of the "gain max, bass half" one). Nice fo' sho, but not gainy enough for me sometimes. My amp tends to smooth out the muff'n a little, so it doesn't sound as high a gain as those clips. Hence the boost.
Im more getting the Mesa tubes as an experiment. I want to see what an AY and an AX in different orders sound like.
Actually thats one reason why I like the Muff'n and doubt there will ever be a replacement for it. I love being able to change out the tubes if I want
EDIT: Not to turn this into a "vs." thing, but there are 2 things the ValveDrive has that make it not a very good comparison to the Muff'n:
1) VD only has 1 tube
2) VD's tone knobs only cut, Muff'n's cut and boost