I wouldn't use the ME50B at all, it sucks out too much punch, no matter in what setting. Get a used GT-6B it has amp and cab modeling and DI built in. 150-250 online.
Gretsch Broadkaster Bass | Markbass Compressore | EBS Fuzzmo
Gallien Krueger MB Fusion 500 | Gallien Krueger NEO212 Cabs