The pickup is the biggest fault in the chain. Improving the amp can't fix a crap signal. If you're off on an engineering bent, make us a pickup
Short of that, something like a Walter Woods with a light, small and tight sounding 12" speaker is best for my tastes. Thus I have a Walter Woods and an Ampeg PB112H.
I really don't care about hi-fi, or even so much how it sounds on stage, as long as it sounds good out front. If the sound is harsh on stage I simply stand off-axis to it. A two-piece deal is my preferred setup, as I can then use my preferred amp on the road with rented speakers, use different cabinets for different applications, and upgrade my rig a piece at a time as my taste/budget/needs/available-equipment changes.