Angled headstock or fender style? Depending on your setup, holding the blank to the table is the toughest part, unless you're fancy and have a vacuum table.
The way I do it is to first machine the fretboard mating surface of the neck blank. I cut three small holes for indexing as well as fretboard alignment. Then the truss and cf slots. Then the headstock surface and tuner holes. Lastly, the perimeter route. It's held to my table with carpet tape.
Then I flip it and use the 3 holes and dowels to help keep it aligned. I also zero off of one of the mating holes in my table before sticking the neck down with tape. I machine the back contour.
There you go. Some sanding and you have your blank. I do the fretboard following the same sort of procedure. Your fretboard then snaps on to your neck using those 3 dowel holes.
I hope that helps.