I play it with my 'normal' sound, bass and mids a bit boosted, high's a lot.
And I play it with my fingers

I have the nasty habit of biting my fingernails, so no nails to strike with, and it never occured to me to play with a pick. (it would be the only song, so bringing half a million picks 'just in case' doesn't sound justified). So on most shows, I'm so nervous I play too hard and end up with bleeding fingers
