I've never done it, but I know some friends who have. They did it as a segue in a song and sometimes part of a hip hop medley. They had 1 drummer, 1 guitarist, 1 bass player, 2 MCs, and 1 dude who did keyboard/horn/turntable/maracas. As you can see, the last dude was the integral part of it. Sounded really good. I can't find any footage of them doing it (the video I made somehow got corrupted), but here's a video of the band doing another song to get an idea of their sound.
http://www.youtube.com/watch?v=jUXpXxwThzI