Here's a quote from an allen and heath 2400 manual. Which can be found
here
Mixing with faders or gain controls? There is a technique
used by some operators where they set all the faders to ‘0’ position
and balance the mix using the channel gain controls. We do not
advise this method as the signal to noise ratio and control resolution
can be severely degraded. In addition, it is impossible to mix monitors
from FOH in this way as changes to the gain settings affect the
monitors too.
The correct method is to use GAIN to match the source to the
operating level of the channel for optimum dynamic range, and then
use the FADERS to balance each source into the mix. With correct
system gain structure, prime sources such as vocals would have their
faders operated around ‘0’ while sources low in the mix such as
backing vocals and acoustically loud brass and drums would display
their true contribution with their lower fader positions. This is a much
more visual and accurate way of mixing.
Although the model is a bit away from what you own I'm sure the principles still hold true. Don't use the gains to mix.
Edit: Oops! I jsut googled an image of what you own. Most of what I posted was irrelavent (thought you had a powered desk) My bad. Still though don't run the master up full.