Ok... I've read a lot of threads on effects loops and running your effects directly or through the loop. I can't find anything that relates to my specific situation. I'll start with my gear, what I'm doing, and what I want. I have: Gk1001rb into an mbx 410 Gk backline600 into an mbx 210 Effects: boss me-50b A large gigs I bring it all out. Medium gigs just the 1001rb and 410 and small gigs I run the backline with 210. I'm primarily concerned with the big rig. I want to run the effects just through the 210 so I can have a blending effect to have effects but keep the natural tone through my other amp. Usually at larger venues the sound guy will take a few channels between both di signals and mic the 410 so he has ultimate control of my tone. Hence the "need" for blending (and so the effects aren't so pronounced). I usually only use compression, chorus, a little od, and a minimal filter effect. My main question is should I run this way blending or run the effects to both cabs? Is there a benefit to using effects loop patch bay? Am I over thinking it? Any suggestions? I've only begun to use effects with my bass and don't want to ruin any tone that I have. Feel free to listen to my main project if the style is of any relevance: reverbnation.com/ashanan Thanks in advance for any advice you can give me. You guys rock!