I had one of these cabs new for about 10yrs and it was my main gigging cab. I found it to have a great sound and extremely articulate, clean hifi sound if somewhat voiced, and has a lot of mids and low mid punch.
One thing I found lacking is the lack of bottom end at any significant volume especially off axis. When I was using it for my jazz funk gigs it sounded perfect all the way through the spectrum, however when I wanted a bit more meat and power on the low end for reggae/Rnb gigs I found that it wasn't giving me the any heavy bottom end at a decent volume to fill a room without pa support.
I recently sold it mainly because of that and also the weight of that cab going up and down stairs and load in and out of the van and car was too much.
I still miss that cab but wouldn't have one again unless someone else was carrying it.
Mesa Boogie Powerhouse 410
MEsa Boogie 410 cab