Well, this is truly making me feel bad. O.k., I powered up my power-amp (for monitors) when my US428 was ON and plugged into the amp (line-outs from 428 connected to power-amp). It was also connected to the USB port. Now neither the sliders nor the transport on the unit itself control the application (Cubasis VST- that came with the controller). Neither do the Select buttons, Solo, Mute, or Null buttons have any effect. Can I fix this? I am, obviously, pretty horrified. I got a message from Windows (XP) that they are getting a report on it for the purpose of fixing the software. Is this a software problem or a hardware problem- and am I screwed? I am kind of begging for an answer to help this out, here. Thanks, Rog.