I would be interested in hearing how people clean their strings in between replacing them. Most of the previous discussion on this topic deals with removing the strings first, which Id like to avoid in this thread as its already been discussed to death. The techniques I have culled from previous posts (and my own comments) are below. 1. Clean your hands first with rubbing alcohol. (I do soap and water wash first. Then rubbing alcohol, which is 70% alcohol, so its tolerable to your skin) I sound like a woman but I like to put a moisturizer on my hands after playing as I have dry skin. There is an alcohol based hand cleaner you can buy in small bottles that contains a gel that can combine these two steps. 2. Use GHS Fast Fret, Never tried it. Any comments would be appreciated. 3. Here is my technique: Wet a cloth with isopropyl alcohol (99% alcohol) and pinch the string at the bridge and pull it up to the nut. Repeat for the other strings. I start at the bridge because you pick/pluck from there so the grime is more concentrated there; hence it gets the benefit of more alcohol and a cleaner cloth. The alcohol might be bad for the fingerboard so any excess alcohol will have come of between the bridge and the fingerboard.