I got a SansAmp BDDI to use at home when I plug straight into the mixer. I found I could get a good growl from the A and D strings, but not E. So I raised the pickup and I got more growl. So I go to practice. I detune to drop D for Another Brick in the Wall Pt 2. My big entrance: "We don't need no education!" ... bink. Next to nothing. Once I detuned the E (now D) was too close to the pickup and I got zilch for output! One quick lowering of the pickup and things are right in the world again.