Yeah, in my band I'm running a Boss DS-1 w/ every knob pretty much at noon, into my sansamp, and then into a tube amp.. I'm getting some feedback when the pedal is engaged. Nothing too nasty, and sometimes eliminated if I mute the strings just right and stand in the right spot.. But is there an easy to fix to eliminate this? Or is that the price to pay for high gain? Hehe.. I'm thinking there are probably feedback eliminating pedals, but I haven't really looked into em.