Currently I run my Mustang directly into an RME, then TH3 and out to studio monitors. I don't jam, gig or do anything else out of my house where I "need" actual gear and I live in a stacked condo where I have neighbours below, behind and beside. That said, I haven't gotten any complaints in the four months I've been here and I don't hear them so... take it for what its worth. TH3 is mostly guitar focused so while the time and pitch effects, amps and cabs for bass are fine, the compressor and overdrive options are lacking. Which matters to me because frankly they are the only effects I use a lot. So my first thought was to grab a compressor and overdrive to feed the RME and call it a day. But GAS being GAS that quickly spiraled into adding a tuner and DI which then became a head with a DI out at which point why not a combo for not much more. Talk me down or... don't. Buy for today? Buy for tomorrow? Buy what you want? Buy what you need?