PODxt

I know this product has been hit or miss around here in terms of those who like it and don't. I was wondering if it be a bad idea to run a pod through my mesa boogie walkbabout head. I have heard some say that if an amp has to much natural coloration and tone that it might skew what the pod will sound like. Is this a bad idea?
Keep in mind i have yet to use a pod with my mesa boogie so any advice will help. Thanks
 
Does anyone know what effects on the PODxt use tracking? Is it just the synth ones? I want to know what effects require a clean bass sound going into the PODxt because I am thinking of using a EHX POG and digitech whammy infront of the POD...