I just switched back to 40's from 45's after a couple of years hoping it would alleviate some rotator cuff and general shoulder pain. I am happy to say it made a huge huge difference. I have no pain at all after 2 church services which usually results in some pain. I feel nearly 100% better. I can't believe it made such a difference. I'm also pretty happy to be back on DR fat beams. I had a 45 gauge signature set of fat beams on for almost 8 years before putting on lo riders for the last year or so. The 40 lites sound thicker then they should. I do not feel like I lost a lot of tone and I love the sound I'm getting. The fat beams have the perfect EQ that seems like its a low shelf eq at 200hz. The flexibility it perfect for me but coming off 45's I imagine anythign would feel more flexy. I wouldn't mind a signature lite set with the 105 e string. anyway. I'm happy and fat beams lites are staying on until they don't make em anymore. I am glad to be back in the fat.