My sister has Parkinson’s that seems increasingly difficult to treat with standard PD meds. I’ve been looking into more advanced alternatives that attempt to “fix” or at least mask the problem at the source: The brain. Layman’s Overview of the options: Deep Brain Stimulation: Small hole drilled in skull, electrode implanted, some kind of device attached. Has a long track record for working well in many patients, but not always lasting. And it’s invasive surgery. I worked with a guy who had this done and he improved dramatically, but within a few months he declined back to his previous state. DBS is by far the most common next-step treatment, but it’s invasive surgery. Hospital stay, risk of infection, longer convalescence. To me this seems like the least attractive of the options even if it’s fairly routine. Gamma Knife: Focused radio waves create a lesion on the brain that kills the cells responsible for tremors. Non-invasive. Seems to be well-accepted. Apparently it’s difficult to achieve precision targeting though. Focused Ultrasound: Fairly new, FDA approved in 2016. Non-invasive, uses MRI technology to achieve a more accurate beam focus for creating the lesion. Not many places offer this yet and it’s not covered by insurance. But the success rate seems fairly high. Anyone have any personal knowledge or know anyone who’s had these treatments? What was the outcome? Thanks.