Weird string spacing

So I was watching the ever so glorious Charles Berthoudand I saw that he was using a 6 string, where the E string is nowhere to be found.
This got me thinking.. Why not adjust my 6 string to be more like that?
It may look bad, aesthetically, but it looks very comfortable to me, a player with short fingers.
Say I put the B at the end and the E has some wider space between it and the A and the rest of the strings are tighter together?

However, I'm wondering if this can have an impact on the neck, as the tension isn't exactly put out evenly, over the neck?