I guess this is akin to the difference between a maple or a rosewood fingerboard. Yes, there is a difference -- but is it really that much? I'm sure there will be those who have experienced a HUGE difference, but I have to say -- after much experimenting, it really doesn't seem to matter much. Now, most of my devices are left on all the time -- EQ, sonic max, compressor. I guess if you're using reverb and overdrive, there's the potential for some more timbre change. But what's the difference between enhancing an EQ or EQing an enhancer? Anyway, I might be in the minority. But I have to believe others have come to a similar conclusion.