How do common guitar cabs get away with this?
On paper, they don't. However, similar to 410 configurations, I don't really notice the off axis response issues that are talked about (primarily in the audiophile stereo literature), at least in the specific situation of amplifying a bass guitar or electric guitar.
I've probably played a 1000 gigs with guitarists using Twin Reverb amps with side by side 12's, and they sound totally even across the stage and across the room when I'm in the audience.
I've also done many A/B's 'on the gig' with various 210 cabs...placing them in vertical and horizontal orientation. Besides a slight perceived increase in absolute low end in some cases when a 210 is placed horizontally (is this due to floor coupling or possibly a reduction in off axis upper mid response due to comb filtering that made the cabs sound 'more bassy'?... I have no idea... it was very subtle), I never really noticed a significant difference across the stage or out in front of the cab. I'm sure it was there, but as a few have pointed out, this sort of 'orientation' effect was overwhelmed by the other acoustical impacts of room, player, amp/cab match, etc., etc., etc., etc.
As Agedhorse points out, there are many, many subtle issues in cabinet design, and each configuration has it's slight positives and negatives. It's better IMO and IME to use your ears when choosing a cabinet or any piece of gear
