Anecdotal ramble time. Not sure if there's really a point to this.
A singer I recently produced a track for tried to do things the old-fashioned way, with real musicians playing everything. After spending a few months, she decided she doesn't want it to sound like that, and the track ended up quite a hybrid of edited real instruments and programmed samples. The bassline was DB back when I played live for her, the first recording was a bass guitarist that the pianist knew, then it was programmed using samples of three tubas and three cimbassi, then it was rerecorded by a sousaphone player, and in the end I time-aligned the sousaphone part to the tubas and cimbassi and mixed them together. Maybe 20 seconds of the drum part got cut up and reused as loops, and the kick drum is a sample from elsewhere. None of the real instrument parts are really completely what the person played, though in the case of the piano it's just muted during some moments.
Now she's going full electronic and not planning to hire any live musicians for performances, because it's too much work to coordinate that many people and get them to learn original material. I wouldn't be surprised if she does get a live violinist and/or pianist at some point, so I rendered all the tracks separately - that way she can always make a backing track minus the musicians she wants to have live.
But at that point we're not looking at "this song had real musicians really playing parts some of them were replaced by backing tracks for live performance". It's more like "this song was a bunch of tracks, some of which originated as people playing this song and some of which didn't, and now some of them might be replaced by real people for live performance".