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2 channel power amp different ohms

Hi I have been looking into 2 channel power amps and have a question:

Say a power amp puts out 500 watts per channel at 4ohms and 300 per channel into 8 ohms for example.

Is it ok to run a 4 ohm cabinet into one channel and the other channel powering an 8 ohm cab at the same time? Im guessing yes these are made for that but just want to make sure.

Thanks!!!!