I played guitar before bass, but haven't played guitar on stage in almost 20 years. I've always been partial to Strats, and have two American Series versions: 2004 alder/maple with Lace Sensor Hot Golds; and 2001 alder/rosewood with OEM Seymour Duncan humbuckers that split in switch positions two (one coil from each) and four (neck only). I prefer the Lace Sensor singles for pure Stratty goodness with lots of punch, but the HH Strat is incredibly versatile, and might be my choice for general purpose rock band use. Both have excellent playability.
Unless you have a strong preference for something specific, like a Gibson SG or Telecaster, I'd recommend starting out with a Fat Strat, i.e., Strat with bridge humbucker. Strats usually have great playability, and the bridge humbucker is much better for high gain than a bridge single. The current Lone Star Strat is awesome; it's an MIM version of the old MIA Texas Special Fat Strat, with Texas Special singles and a Duncan Pearly Gates Plus at the bridge. That's the same bridge pickup in my HH Strat, and it's sweet.
If you're mostly into rock, you can't go wrong with an SG either. I'd love to have a white one, with Burstbucker p'ups please!