I'll chime in, as I've been running through a SansAmp BDDI for several years now but have recently added a Bass-Drive and ditched the SansAmp... If the SansAmp sound is your thing, great. It was for me for several years. However, I found my use of it changing as I had it. When I first got it (I was playing through an older Peavey Basic 112 amp, I believe), I was running it with the blend all the way up and the bass and drive cranked a good bit as well. Meanwhile, I had the treble on the SansAmp and my amp cut a lot. While it gave me a FAT sound, I'm sure it stretched that 50-watt amp trying to pump out that much bass clearly, and it didn't cut through the mix very well. Over time, I found myself wanting more and more mids, so I wound up doing just what Boo mentioned... cutting the bass and treble and boosting the level. It still had that SansAmp sound, but I could cut through a lot better. Later still (after switching to my current amp, a Fender Rumble 100), I found that I actually liked the sound of my amp, too, and I started running the blend at about 50/50, still with that same mid-boost. Then I got my Bass-Drive. It can go from over-the-top (for me) heavy to light and warm. With it, I can have the crystal clear clean tone of my amp (not that I couldn't have turned off the SansAmp before, but something in me just seemed to think that if it was in the signal chain it needed to be on... I saw it more as an integral part my sound instead of an effect), a slightly overdriven tone, or a hefty grit... all without the SansAmp and all without losing any mids. Anyway, the point of all this? Like I said, if the SansAmp sound works for you, keep it and find a good eq to put after it (while I haven't played one, I have heard good things about that MXR 10-band). But I'll second the recommendation of the Bass-Drive, as it's a great, versatile tool that doesn't cut your mids (and can even boost them a bit in vintage mode).
Brian
P.S. By the way, while the Yamaha NE-1 does cut the mids, it's also a pretty versatile tool. Between the shallow and deep Q settings and the frequency range (anywhere from 150 Hz-10kHz, depending on the Q), you can use it to filter out any "problem" frequencies you may have. So while it's still probably not what you're looking for, it's also not gonna cut your mids like a SansAmp with the bass and treble cranked will... Okay, I'm done.
Brian
P.S. By the way, while the Yamaha NE-1 does cut the mids, it's also a pretty versatile tool. Between the shallow and deep Q settings and the frequency range (anywhere from 150 Hz-10kHz, depending on the Q), you can use it to filter out any "problem" frequencies you may have. So while it's still probably not what you're looking for, it's also not gonna cut your mids like a SansAmp with the bass and treble cranked will... Okay, I'm done.