It also depends on your platform and how much your CPU is taxed with chores other than moving audio while it's moving. Very, very generally, Windows users suffer from some FW issues that Mac users don't because of drivers that have to be written that aren't part of the system (as in OSX), yet they have somewhat less USB audio problems because of the differences in how the OSs handle it. As well as all the aforementioned info about how data is handled differently by them. USB was developed as a peripheral bus, to move data and just get it there as fast as it (and the CPU) could, eventually. Firewire was specifically created to move audio and video with their attendant differences from other data. It's basically anecdotal, but as a Mac user FW has always been bulletproof for me, while USB2 just doesn't function "as advertised", and I certainly can't have hardly anything else going on with the CPU. I have PC friends who don't have the USB hatred I do yet can't make the simplest FW interface work up to spec.
So it depends on a lot. Plus, you can get ANY interface on ANYthing really. Skip LaCie. Lots of dead LaCie power supplies in their external drives. I would recommend checking out Other World Computing
http://eshop.macsales.com/shop/firewire/
and simply get whatever ports you need with the biggest you can muster.
As far as USB or FW for the interface, USB is found on the ones with less taxing units for a reason: It "works" on them, 2 input, 4 input. But anything above that is generally FW. What is your expected recording situation? Always you creating the tracks? Recording your band? Tell us! : )